PINK1 Deficiency Aggravates the β-amyloid-attenuated Mitophagy-lysosomal Degradation in PC12 Cells
نویسندگان
چکیده
Background and objectivePTEN-induced putative kinase 1 (PINK1) is a mitochondrial that regulates mitophagy. PINK1-deficient mAPP mice display low LC3B levels, PINK1 overexpression enhances autophagy increases the expression level of lysosome-associated membrane protein (LAMP1). The present study evaluated whether altered could modulate β-amyloid (Aβ)-treated mitophagy in PC12 cells, simple cellular model to simulate pathological changes neurodegenerative diseases vitro.
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ژورنال
عنوان ژورنال: Journal of exploratory research in pharmacology
سال: 2022
ISSN: ['2572-5505']
DOI: https://doi.org/10.14218/jerp.2021.00053